RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
PTGER2
RNA ID
RNA Type
mRNA
Alteration Pattern
dna hypermethylation
Species
homo sapiens
Detection Methods
Global DNA methylation assay; qRT-PCR; Immunoblot etc.
Target
NA
Pathway
PTEN-AKT signaling pathway
PubMed ID
Title
Hypermethylation of PTGER2 confers prostaglandin E2 resistance in fibrotic fibroblasts from humansand mice
Year
2010
Function
The down-regulation of PTGER2 and consequent PGE2 resistance are both mediated by DNA hypermethylation; Increased Akt signal transduction as a novel mechanism that promotes DNA hypermethylation during fibrogenesis.